Systane Vs Systane Ultra (Which Is The Better Lubricant?)

Systane Vs Systane Ultra: Dry eyes? Let’s check out which is the better lubricant for your eyes!

Whether you suffer mild or severe eye dryness, the implications of it are uncomfortable experiences. The only salvation from this torture is applying appropriate lubrication.

Systane vs Systane Ultra offers insightful information on eye lubricants depending on the intensity of your dry eye. Read on for more.

Systane Vs Systane Ultra
Systane Vs Systane Ultra

I encounter at least one or two patients with eye-associated issues at my workplace. Being a doctor for seven years, that’s at least several hundred issues of eye problems.

Most of them experience dryness that may be related to some pre-existing condition or that arises from their environment and or activities. Most of these cases usually need a good lubricant to keep the eye moist and lubricated.

Out of all the different eye drop options out there, there are two options that I often recommend patients to use. Both are effective lubricants that are effective for use for mild to severe eye dryness. Take a look at Systane vs. Systane Ultra for more on lubrication.

What are the differences between Systane Vs Systane Ultra?

Active ingredient
Polyethylene Glycol 400 0.4%


Propylene Glycol 0.3%

Relieve dry eye
Systane Ultra
Polyethylene Glycol 400 0.4%


Propylene Glycol 0.3%

Relieve burning and irritation from dryness

Systane vs. Systane Ultra – How do these eye lubricants compare?

Degree of lubrication

While both Systane and Systane Ultra are produced as lubricating eye drops, they have varying moisturizing power. Because the ultra has a higher viscosity, it is more soothing and has a greater lubricating effect. The gel like nature is especially useful when you experience severe dryness.

The regular version has ‘regular’ viscosity and therefore not as lubricating as Ultra. Sure both these options are good for dry eyes, but their difference in viscosity makes Ultra a better lubricant especially in heavy duty lubrication tasks.


You may use both brands for various instances of dry eye. Systane Ultra is however much more effective in severe conditions as compared to the regular strength version. You may apply it if you suffer from extreme eye dryness without constant reapplication or dissatisfaction with the result.

Systane is a good lubricant but it is not as high-performance as Systane Ultra. It is ideal for mild to intermediate eye dryness. You may use the Ultra version across this dryness spectrum and it will still prove effective in every instance.

Preservative-free options

Both of these drops have preservatives. Additionally, both of them have single-dose preservative-free versions if you have sensitive eyes but still require lubrication every so often.

These preservative-free vials are ideal for anyone who still wants to combat dryness with systane but cannot use the preservative-inclusive versions.

Systane vs Systane Ultra- A comparison review


Systane: Long Lasting
Systane: Long Lasting

When faced with regular cases of dry eye, Systane is a good remedy option. It will help restore moisture to your eyes and keep them refreshed for a long time. Even when conditions do not favor natural lubrication, Systane offers a fast-acting, long-lasting option and protects you from further irritation due to prolonged dryness. Systane acts as artificial tears to remedy irritation in instances of eye dryness.

This drug combines the power of both Polyethylene Glycol 400 0.4% Propylene Glycol 0.3% as its active ingredients. These compounds offer lubrication for dry, gritty, scratchy eyes. The soothing effect they impart makes Systane ideal for use in dry eye therapy. You may apply one or two drops of these drops to each affected eye as often as you need to.

What we like

  • Great remedy against dry eye
  • This drug is both fast-acting and long-lasting, therefore saving you prolonged eye irritation

What we don’t like

  • Overusing Systane puts you at risk of suffering the side effects or negative effects of an overdose

Systane Ultra

Systane Ultra: High Performance
Systane Ultra: High Performance

Systane Ultra is a combination of various ingredients, some of which occur naturally in tears. These compounds are blended to formulate a high-performing lubricant for instances of severe eye dryness. The active ingredients Polyethylene Glycol 400 0.4% and Propylene Glycol 0.3% confer Systane Ultra its lubricating effect. These drops provide relief from irritation, burning, and discomfort that arises due to dryness. This drug is both fast-acting and long-lasting. Made with the newest dry eye technology, Systane Ultra will soothe the discomfort that comes with dry eye syndrome and assure moisturized and refreshing conditions.

In instances of grittiness, tired eyes with blurry vision, and irritation, one or two drops of systane Ultra should be enough to soothe the affected eye. Although it is a drop, it behaves as a gel that coats the eye, intensively moisturizing and restoring your ocular surface. You may use Systane as regularly as you need throughout the day. The frequency of application will depend on the severity of your dry eye

What we like

  • Systane Ultra is great for severe dryness
  • The lubricating effect is long-lasting

What we don’t like

  • It May cause temporarily blurred vision when first used

Final word on Systane vs Systane Ultra

When choosing the right eye lubricant, there are a number of factors to consider. The severity of your dry eye plays a big part in influencing the type of lubricant you need. Systane and Systane Ultra are good examples of two similar lubricants whose difference is based on the intensity with which they act on dryness. Both of these are good options every dry eye sufferer should consider.

FAQs on Systane vs Systane Ultra

What is the active ingredient in systane?

Polyethylene Glycol 400 0.4% and Propylene Glycol 0.3% are both used as Lubricating agents in Systane. These ingredients are what soothe and refresh the ocular surface.

What are the side effects of Systane Ultra?

Apart from blurred vision, and a burning/stinging feeling that may temporarily occur, you suffer the risk of developing an allergic reaction to the drug.

What is Systane eye drops made of?

There are a number of active and inactive ingredients that are used to make Systane lubricating eye drops. Polyethylene Glycol 400 0.4% and Propylene Glycol 0.3% are the two active ingredients responsible for the lubricating action in Systane.

Can I use systane with contacts?

Yes and no. Contact wearers may use Systane; however, before applying Systane, you are advised to remove your contacts, apply the drops, wait ten to fifteen minutes and reapply your contacts.

Having been a victim of counterfeit products Marie Stevenson decided to comb various markets both online and physical to find the best original beauty products for women. The influx of counterfeits is palpitation inducing especially when you consider the aftermath. The consequences of using fake makeup or tanning lotions can be quite expensive and life-threatening and the reason why Marie decided to provide you with insightful information that will actually enhance your health. Apart from saving the world from the influx of fake beauty products Marie is a dedicated environmentalist, loves to travel and read. Her famous line is that if you believe it and have the passion to do something right then don’t let someone else discourage since they don’t understand where you are coming from.