Visine Vs Systane Ultra (Which Is Better: Redness Relief Or Maximum Hydration?)

Redness relief products are a dime a dozen, but they are not the same.

For example, some contain ingredients that most people can’t pronounce, while others are filled with sodium hyaluronate, a moisturizing ingredient that has been linked to irritation and allergies.

We’ve tested Visine, a redness relief product that is one of the most highly recommended by dermatologists, and Systane Ultra, which has a “maximum hydration” formula that contains hyaluronic acid.

Here are our thoughts on these two products: Visine vs. systane Ultra offer each maximum relief depending on your condition.  

My Own Experience

When you work in high school as a school nurse, you must be equipped to handle any and all sorts of trouble.

Eye issues are especially popular among students.

Many of them come in during school hours with reddened eyes from an extended swimming class or dry irritation.

I have found that some drops work well but there are two exceptional eye drops brands that are helpful in many situations.

If you encounter redness and dry eyes on a regular basis, take a look at my go-to options for eye relief Visine vs. Systane Ultra.

What are the differences between Visine and Systane Ultra?

Active ingredient
Tetrahydrozoline hydrochloride 0.05%
Relieve redness
Systane Ultra
Polyethylene Glycol 400 0.4%

Propylene Glycol 0.3%

Relieve burning and irritation from dryness

Visine Vs Systane Ultra – How they compare


Visine is meant to ease redness caused by a number of factors including dust, smoke, sleeplessness, and staring at the monitor too long.

It also serves to lubricate and moisturize an irritated eye.

This dual function is not present in Systane Ultra which is exclusively for lubricative purposes.

Systane is made to combat dry eye syndrome and may prove ineffective against redness.

Active ingredients

The difference in the function of both these drugs is attributed to their separate active ingredients.

Visine contains Tetrahyrozoline hydrochloride, a decongestant that is responsible for reducing redness.

It also contains a combination of lubricants which for a unique moisture blend to lubricate the eye for a refreshing effect that can last several hours.

Systane Ultra on the other hand has only lubricated as its active ingredients and therefore only offers relief from dryness and irritation.


Both Visine and Systane are ideal for many types of patients including contact lens users.

However, the lenses must be off prior to application.

You may use either of these drugs at any time in the day but Visine has a maximum 4 times limit.

Systane Ultra is safe for use as needed.

You need only apply one or two drops in the affected eye as you see fit.

Visine vs Systane Ultra- A comparison review


Visine Maximum Strength Eye Redness Relief Formula Eye Drops to Moisturize and Refresh Irritated and Red Eyes, 0.5 fl. oz

Visine Maximum Strength is formulated to ease redness caused by your external environment.

When you encounter smoke, smoke, dust, or other irritants, your eyes may turn red, become itchy and uncomfortable.

With Tetrahydrozoline hydrochloride as its active ingredient, Visine can narrow the blood vessels in the eye and reduce the appearance of redness.

Additionally, it has some lubricants that moisturize the eye and reduce dry discomfort.

You may use Visine regularly for temporary relief from dryness and redness due to the sun or wind.

Any patient over the age of six can use one to two drops of the drug in the affected eye for relief and long-lasting protection against further irritation.

It is okay to use Visine up to four times a day depending on the intensity of your eye irritation.

What we like

  • It serves the dual function to relieve redness and lubricate the eye
  • You may safely use it multiple times throughout the day

What we don’t like

  • Overuse may lead to more eye redness


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Systane Ultra

Systane Ultra Lubricant Eye Drops

Systane Ultra is a high-performance brand of artificial tears useful for dryness and irritation.

These drops are designed to help lubricate and refresh the eye, leaving you feeling moisturized.

It keeps the ocular surface healthy for extended periods.

With a combination of new eye drop technology, Systane Ultra can remedy many dry eye-related situation.

The drops themselves are light but their extent of effectiveness can be compared to that of a gel.

With Systane Ultra all dryness, burning, gritty, tired or irritated eyes are refreshed.

In addition to being an exceptional form of artificial tears, Systane Ultra can be used severally throughout the day without the worry of overdose.

Although some people may experience side effects from using this drug, the chances of severe reactions from its use are rare.

The product has lubricants as the active ingredients that

What we like

  • It is high performance for dry eye symptom relief
  • Systane Ultra is great for long lasting lubrication and moisture

What we don’t like

  • Your vision may blur when you first start using Systane Ultra


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Final word

Finding the best eye drop option starts with understanding the cause and nature of your eye problems.

Once you determine the problem, choosing the appropriate remedy should not be as difficult.

In instances of nonallergy associated redness, I find Visine Maximum Strength to be quite useful.

When experiencing dry eye syndrome, Systane Ultra provides maximum lubrication and moisture to put your discomfort to rest.

These guidelines should be useful in your selection for the most appropriate quick and long-lasting solution to your eye issues.

People also ask

Is Tetrahydrozoline bad for the eyes?

It is a decongestant that acts as the active ingredient in some eye drops. Some brands combine this active ingredient with lubricants to not only remedy redness from irritants but to keep the eye from getting further irritated.

Can you use Visine Maximum with contacts?

When using Visine, you are advised to remove your contacts before application.

After using the drops, wait for ten to fifteen minutes before you wear them again.

What are Systane eye drops used for?

Systane Ultra Is a high-performance eye drop that refreshes the eye and replenishes moisture leaving it well lubricated.

It is an effective tool against dry eye syndrome and all the negative effects that accompany it.

How often should I use Systane eye drops?

Systane is safe to use as often as needed.

You need only apply one or two drops to the affected eye.

The formulation is long-lasting and does not require constant reapplication.

What is good for dry eyes?

Lubrication and moisturization is the remedy for dry eyes.

Eye drops offer this much-needed moisture and alleviate the effects and discomfort of dry eyes.



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